Wampum Soothing Skin Spray can completely solve 85% of all skin itching cases and alleviate the balance to a very large extent. The spray contains 4 skin actives, 2 natural ones and two conventional medicinal ones: comfrey extract, witch hazel extract, salicylic acid and allantoin. It can be used safely with any other medication. It is water-based so there is no residual cream base for the dog to keep licking at.